Sounds like a great idea, but for a game that size, you might not be all that happy using Access as the database.
You might want to do some early estimates of size (based on any of your larger campaigns) to get an idea of how big the database will get.
You need to consider number of systems, colonies, ships, designs, events, etc. You have a limit of 2 GB for everything... and with all the new commercial stuff and NPR activity, things will grow at a fairly rapid pace.
It'd really suck to have a great storyline going and then slam into the 2 GB wall.