The particle lance will definitely be interesting. Note that you don't have to go with all options - I'll probably field small regular beams for long-range work, and look at large but otherwise low-tech lances as can openers after which other weapons can find the gaps. Paying for capability you don't need becomes less attractive when a weapon has a chance to break down each shot. OTOH, microwaves probably remain the top choice against heavy armour - doesn't matter if destruction takes a while after the enemy has been render deaf, dumb, blind and impotent.
I see little use for the new mesons unless shields turn out to be oppressive. Apart from PDCs, I found them dubious despite all the advantages they will no longer enjoy. I believe the upcoming version will be interesting and a little weird - to my understanding, a great many mechanics changes encourage something rather counterintuitive.