I don't really like fighting against the game mechanics like that. In my opinion, it's better if they support whatever I'm trying to roleplay and having not to pretend something isn't happening in the way it is in the game. Besides, I like being somewhat informative and critical in my commentary and not just someone who accepts everything indiscriminately. I believe a critical mindset will lead to progress in society.
There are a couple of restrictions I do have: I will avoid researching shields and cloaking unless I am also prepared to give a scientific explanation on how they work. However, conventional thrust is something that was unavoidable not to have since if I want to have spaceships at all, I'm pretty much forced to rely on the game mechanics for the thrust model. That's where I feel like I'm fighting against the game mechanics the most since it's something "unavoidable". There are a couple of smaller things like not being able to have unmanned ships, the spaceships not having radiators, etc.
Of course I'm adding things that aren't explained in the game mechanics, such as any unintelligent extraterrestrial life. Right now there is only one place I've found at least somewhat suitable for that but I feel it's going to be very interesting once I find more planets that I feel like putting life on.