One can assume that a missile, the engine and fuel, have less mass than a solid projectile of the same size, thus, a guided projectile would require a larger caliber railgun to fire a projectile of the same kinetic energy.
Additionally, given other factors of space combat, there is a great range of possibilities affecting the efficiency of weapons.
If your ship is going 150k anyways, the 70 you might get from the railgun could be substituted for slightly larger projectiles, and you'd be directly firing guided missiles.
Especially on ranges that have 30+ seconds slight time anyways.
However, one could assume to use the maneuvering engines to give additional thrust, yet still the gain would be too marginal.
If, instead, the range of the engagement is within just a few hundred kilometers, a guided projectile does not measurably increase the hitrate, while reducing the firerate(or damage output).
And wouldn't a defensive nuke be able to blind/damage a guided projectile, thus eliminating the advantage?
What about electronic warfare/decoys to simulate a ship shortly, maybe not able to confuse a ship-board sensor, but the small homing device of the projectile? Direct guidance might result in delay and thus give up part of the advantage, while directed ECM will food the guidance of such a small projectile that will have to be either conductive, and thus magnetic, allowing pulse magnet fields to alter it's course and damage electronics, or not, in which case it's not shielded from a medium-powered, and a lot faster-fireing, microwave laser to take it out.
Sure, these a re all very small caveats, but;
Given that a guided bomb is quite probably several hundred times more expensive than a chunk of metal, and more prone to failure, it raises the question if it wouldn't be drastically more economic, if less effective, to just mount more guns and fire a storm of standard pellets. Or leave out the railgun in favor of boxlaunchers.^^