Just a general observation: Technology allows us to change roles quickly.
As a human, we can't breathe underwater, fly, go in space, or sustain any kind of physical trauma. With technology, that all changes. Further, it changes on a temporary basis. We can grab SCUBA gear, or get in an airplane, or fly a space shuttle, or wear armor. A living organism is effectively static while it is alive; it can't change roles. Also, individually, each piece of technology can do the job better than an organism. Individually we can make submarines that outperform sperm whales, power plants that produce ridiculous amounts of energy, etc. Of course, you can't expect submarines to breed or colonize a planet, but at least their occupants can get out of the submarine and get onto an airplane or a spaceship and do the colonizing themselves, in their own lifetimes.
I'm a biologist and my own personal area of fascination is closed ecological life support systems (CELSS). I've done a lot of reading of NASA's research and the Biosphere experiments. I happen to think greenhouses are the way to go for big long missions. There's something to be said, though, for the simplicity and complete reliability of mechanical life support and I doubt any ship life support will run solely on plant/algae/fish with no mechanical backup. Small ships will most likely always be mechanical. If your living life support system gets out of balance, you're in trouble.
TallTroll, a quick side note: popular definition of the term 'organic' is quite different from the various scientific definitions. In general, we should clarify if our definitions vary from the popular definitions, especially if you specialize in a field. Serious problems have arisen in the past when scientifically trained people assume the audience uses words in the same way as the speaker. I understand and sympathize with the viewpoint of organic chemistry, of course, and have been through dozens of discussions about this in the real world (organic pesticide, organic food, organic medicine, organic this organic that). This is a conclusion I've drawn after a lot of hard experience. Almost nobody engages in a real-world, non-professional discussion involving the word 'organic' with 'carbon-containing' in mind.